ʻO ka hoʻohana hou ʻana o ka phenylmethylamino acid-he milestone hou i ka hoʻolaha ʻana i ka holomua ʻepekema a me ka ʻenehana a me ka hoʻomohala olakino.

I nā makahiki i hala iho nei, ʻo ka noiʻi maNā ʻakika Benzylamino(Benzylation of Amino Acids) ua hoʻokipa nui ʻia. ʻO ka waikawa Benzylamino kahi hana synthesis kemika, hiki ke hoʻokō i nā loli hana ma o ka hoʻokomo ʻana i nā pūʻulu benzyl i loko o nā molekele amino acid, a loaʻa iā ia nā manaʻo ākea ākea. ʻO nā amino acids nā papa kūkulu kumu o nā protein, a he mea koʻikoʻi ko lākou mau waiwai a me nā hale i ka hana o nā protein. Ma ka hoʻokomo ʻana i nā pūʻulu benzyl, e hoʻololi ʻia nā waiwai physicochemical o nā molekole amino acid, a laila e hoʻonui ai i kāna noi i ka lāʻau lapaʻau, ʻepekema waiwai a me ka synthesis organik.

Ma ke kahua o ka lāʻau lapaʻau, hoʻohana nui ʻia ka noiʻi ʻana i ka phenylmethyl amino acid i ka synthesis lāʻau. ʻO kona hiki ke hoʻolauna i nā hui benzyl e hāʻawi i nā molekala lāʻau me kahi ʻano paʻa a me kahi manawa e hoʻomaikaʻi ai i kā lākou absorbability. Hiki ke hoʻoponopono ʻia ka hydrophilicity a me ka lipid solubility o nā molekele lāʻau ma ka hoʻokomo ʻana i nā hui benzyl, a laila e hoʻomaikaʻi ai i kā lākou hana pharmacological a me ka bioavailability. Hāʻawi kēia i nā mea hou aʻe no ka hoʻomohala ʻana i nā lāʻau lapaʻau hou a hoʻolaha i ka hana hou a me ka hoʻomohala ʻana i ka lāʻau lapaʻau. Eia kekahi, loaʻa i ka phenylmethylamic acid ka nui o nā noi i hiki ke hoʻohana ʻia i ka ʻenehana ʻepekema.

Ma ka mālama ʻana i nā kūlana synthesis, hiki ke hoʻomākaukau ʻia nā mea polymer me nā hana kikoʻī. Hiki i ka hoʻokomo ʻana o nā pūʻulu benzyl ke hoʻoponopono i ka hana o ka ʻili a me nā waiwai mechanical o nā mea, e hoʻomaikaʻi ai i ka hana a me ka hana o nā mea. He hopena koʻikoʻi kēia no ka hoʻomohala ʻana i nā kahua e like me nā mea pākaukau, catalysts a me nā mea ʻike. Eia kekahi, ʻo ka hoʻomohala ʻana i ke ʻano p-benzyl amino acid he mea nui hoʻi i ka synthesis organik. Ke hoʻohana nei i kēia ʻano hana, hiki i nā mea noiʻi ke hoʻololi pololei i ke ʻano o nā molekole amino acid e synthesize i nā pūhui organik me nā hana kikoʻī, e like me nā intermediates lāʻau a me nā moleke hana. Hāʻawi kēia i kahi kahua ākea no ka kemika synthetic organik a paipai i ka hoʻomohala hou ʻana o ka kemika organik.

I kēia manawa, ua hana ʻia kahi ʻano o nā mea nui i ka noiʻi ʻana i ka waika p-phenylmethylamino. Ma ka ʻaoʻao hoʻokahi, e pili ana i nā ʻano synthesis, hoʻomaʻamaʻa mau ka poʻe noiʻi i nā kūlana hopena a me nā ʻōnaehana catalyst e hoʻomaikaʻi ai i ka hopena hopena a me ka koho. Ma ka ʻaoʻao ʻē aʻe, ma ke ʻano o nā kahua noi, ua hoʻohana nui ʻia ke ʻano phenylmethylamino acid i ka ʻike ʻana i ka lāʻau lapaʻau a me ka ʻepekema waiwai, a ua loaʻa i nā hopena koʻikoʻi. Ma kahi huaʻōlelo, ʻo ka noiʻi a me ka noi ʻana o ka p-phenylmethylamino acid e hāʻawi maikaʻi i ka hoʻomohala ʻana i ka ʻepekema a me ka ʻenehana. ʻO ka hoʻohana hou ʻana o kēia ʻano hana ʻaʻole ia e hāpai wale i ka hoʻomohala ʻana i ke kahua o ka lāʻau lapaʻau, akā lawe pū kekahi i nā holomua hou a me nā hana hou i nā ʻano ʻepekema waiwai a me ka synthesis organik. Ke manaʻoʻiʻo nei me ka hoʻoikaika ʻana o nā mea noiʻi hou aku, ʻo ka noi ʻana o ka phenylmethylamino acid e hōʻike i kahi ākea ākea i ka wā e hiki mai ana.